Deciding on Concurrent COVID, RSV, and Flu Vaccinations, 2023.
In a significant milestone, vaccines for COVID-19, influenza (the flu), and respiratory syncytial virus (RSV) are now available in the United States. Health officials are encouraging eligible Americans to consider receiving all three vaccines to mitigate the risk of a “tripledemic” this fall and winter.
However, this has led to questions about whether to take all three shots simultaneously or space them out.
For most individuals, the decision revolves around getting an updated Pfizer or Moderna COVID-19 shot and a flu vaccine, both of which are widely accessible. Public health authorities, medical professionals, and recent studies indicate that receiving these vaccines during the same doctor’s visit or pharmacy visit is safe and effective.

In contrast, around 76.5 million adults aged 60 and older are eligible for the new RSV vaccine developed by Pfizer or GSK. This group faces the challenge of juggling all three shots this fall. A maternal RSV vaccine from Pfizer exists to protect infants, but it is not yet widely available.
Health experts suggest there is little reason to be concerned about receiving all three vaccines simultaneously. While there is limited research on administering an RSV shot alongside another vaccine, experts don’t foresee any issues. However, if individuals feel more comfortable spacing them out, they can opt for the RSV jab and schedule the other two shots for another time.
Ultimately, the decision lies with the individual, and consulting a healthcare professional for guidance is encouraged.

Dr. Ali Alhassani, a Boston Children’s Hospital physician, emphasized that there is no evidence suggesting any risk in receiving all three shots simultaneously. He pointed out that administering multiple vaccines is not uncommon, especially for children who often receive up to five routine immunizations at once.
Dr. Andrew Pekosz, a professor at the Johns Hopkins Bloomberg School of Public Health, echoed this sentiment, stating that there likely won’t be any issues with combining these vaccines. However, he also highlighted the need for more comprehensive data, leading to caution in recommending simultaneous administration.

The availability of COVID-19, flu, and RSV vaccines presents an opportunity to bolster immunity against these respiratory viruses. Deciding whether to take all three vaccines together or separately depends on several factors:
- Risk Assessment: Individuals should consider their risk factors for severe illness from each virus. High-risk groups, such as older adults and those with underlying health conditions, may prioritize receiving all three vaccines simultaneously for maximum protection.
- Convenience: Convenience plays a crucial role in vaccine uptake. Some people prefer the convenience of getting all three shots in one visit, while others may opt for spacing them out to manage potential side effects or logistics.
- Healthcare Guidance: Consulting with healthcare providers is essential for making informed decisions. They can assess an individual’s unique health status and recommend an appropriate vaccination schedule.
- Emerging Data: As more research becomes available, recommendations may evolve. Staying informed about the latest findings and guidance from health authorities is crucial.
- Individual Comfort: Personal comfort levels and preferences should be respected. If someone hesitates about receiving multiple vaccines simultaneously, they can space them out.
It’s important to note that, as of now, the consensus among experts is that combining these vaccines is likely safe and effective. However, individual circumstances and preferences vary, and the choice should be made in consultation with healthcare professionals.
In conclusion, the availability of COVID-19, flu, and RSV vaccines offers a unique opportunity to bolster immunity and reduce the risk of a “tripledemic.” While experts believe that receiving all three vaccines together is safe, individuals have the flexibility to make the choice that aligns with their health status, comfort, and guidance from healthcare providers.
Staying informed and taking proactive steps to protect against these respiratory viruses is essential as we navigate the ongoing challenges of the pandemic.
Opting for all three vaccines together offers several benefits, making it a convenient choice for many individuals. Dr. Alhassani emphasized that the most significant advantage is convenience, especially for those with busy schedules.
Furthermore, research indicates that individuals often fail to return for their second vaccine dose. This challenge has been observed with vaccines such as the HPV vaccine, where the uptake declines between the initial and subsequent doses. A similar issue arose during the initial COVID-19 vaccine rollout in 2020 and 2021, with many missing their second primary series dose.
Dr. Pekosz from Johns Hopkins highlighted that requiring multiple visits to a pharmacy or clinic often results in attrition rates, as people may become too occupied to return for their subsequent shots. Therefore, receiving all vaccines during a single visit is a more practical approach.
Pharmacies are accommodating this convenience factor by enabling Americans to schedule multiple vaccine appointments in a single trip. For example, Kroger’s online scheduling tool allows eligible individuals to choose up to three vaccines to be administered simultaneously.
Kroger Health’s chief medical officer, Dr. Marc Watkins, mentioned that their clinicians, pharmacists, and physician assistants assist people in determining the appropriateness of taking these vaccines together.
Options for Those Preferring to Space Vaccines Out
Some individuals may opt to delay receiving all three shots together. This choice can stem from a desire to await additional data or for physical comfort, as Dr. Alhassani noted from Boston Children’s Hospital.
One common side effect of vaccines is inflammation or soreness at the injection site. As a result, individuals who need two shots during the same doctor’s visit typically receive one in each arm. However, some people may prefer not to experience the discomfort of receiving three shots simultaneously, whether in one arm or two.
This preference is especially relevant for those engaged in activities that require frequent arm movement, such as athletes or teachers who write extensively on chalkboards or whiteboards.
For those choosing to receive the three vaccines separately, Dr. Pekosz recommends a specific order and timing. He advises getting the updated COVID-19 vaccine as soon as possible, followed by the RSV shot and then the flu vaccine. A one-week interval between each shot is recommended, as this approach reduces the likelihood of individuals missing their subsequent vaccinations.

Dr. Pekosz determined the order of vaccines based on the current prevalence of these respiratory viruses in the U.S. Given the higher levels of COVID-19 transmission, the updated COVID-19 vaccine takes priority. COVID-19 hospitalizations have been on the rise in the U.S., according to the latest CDC data.
While RSV cases are starting to increase, particularly in certain parts of the Southeast, influenza remains relatively dormant. Therefore, individuals can also opt to receive their COVID-19 and flu vaccines concurrently, reserving the RSV vaccine for a week later. This approach aligns with scientific evidence supporting co-administration of vaccines.
In conclusion, individuals have the flexibility to choose between receiving all three vaccines together or spacing them out based on their convenience, comfort, and guidance from healthcare professionals. Convenience, reducing attrition rates, and accommodating busy schedules make simultaneous administration a practical choice.
However, for those preferring a staggered approach, following the recommended order and timing ensures optimal protection against these respiratory viruses while minimizing the risk of missed vaccinations.








